Nutritional Articles

Effects of monoamines formed in the cecum of horses on equine digital blood vessels and platelets.

Published: 2004-04-15

Effects of monoamines formed in the cecum of horses on equine digital blood vessels and platelets.
Studies in other species than the horse, have indicated that amines (which are a result of the decorboxylation of amino acids), especially those arising from aromatic amino acids, have vasoactive effects. The production of monoamines may play a role in the pathogenesis of laminitis as some amines have been shown to increase 2- to 3-fold over a 24-hour period in vitro models of carbohydrate overload. To determine in vitro vasoactive potency of monoamines formed in the caecum and found in the systemic circulation of horses the authors studied the effect of various aromatic amines on the vasoconstriction of equine digital arteries and veins. On the basis of their experiment the authors concluded that amines from the equine cecum cause digital vasoconstriction. The authors concluded that further research regarding the influence of amines formed in the cecum and released into the systemic circulation and their role as possible trigger factors for digital ischemia and subsequent laminitis is needed.

Reference
Elliott, J. Berhane, Y and Bailey, S.R. 2003. Effects of monoamines formed in the cecum of horses on equine digital blood vessels and platelets. American Journal of Veterinary Research 64: 1124-1131.

Website and Publisher
http://www.avma.org/publications/ajvr/ajvrifa.asp