Effects of the omega-3 fatty acid, α-linolenic acid, on lipopolysaccheride-synovial explants from horses
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The objective of this study was to determine the effects of pretreatment with α-linolenic acid, an omega-3 polyunsaturated fatty acid, on equine synovial explants challenged with lipopolysaccheride (LPS). The authors assigned synovial explants of 8 horses to receive 1 to 7 concentrations of α-linolenic acid ranging from 0 to 300 μg/ml. Half of the explants were controls and half were challenged with LPS as a model of synovial inflammation. The authors observed that treatment of α-linolenic acid at the highest dose inhibited prostaglandine E2 production. Furher, α-linolenic acid did not alter cell viability and histomorphologic characteristics. Explant cell membranes treated with α-linolenic acid showed a higher percentage of this fatty acid. The authors concluded that further research regarding the use of α-linolenic acid as and anti-inflammatory medication for equine synovitis is warranted.
Munsterman, A.S., Bertone, A.L., Zachos, T.A. and Weisbrode, S.E. 2005. Effects of the omega-3 fatty acid, α-linolenic acid, on lipopolysaccheride-synovial explants from horses. AJVR 66: 1503-1508.
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