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Phenotypic expression of equine articular chondrocytes grown in three-dimensional cultures supplemented with supraphysiologic concentrations of insulin-like growth factor-I
Fortier, L.A., A.J. Nixon and G. Lust
Brief content of the article:
The objective of this study was to assess the effects of supraphysiologic concentrations of insulin-like growth factor-1 (IGF-1) on morphologic and phenotypic responses of chondrocytes. Chondrocytes were suspended in fibrin cultures and supplemented with 25, 12.5, or 0 mg of IGF-1/ml of fibrin. The researchers found that the 12.5 and 25 supplementations resulted in an enhanced phenotypic expression of chondrocytes without inducing detrimental cellular or metabolic effects. The authors wrote that the results of this study suggest that application of such composites for in vivo use during cartilage grafting procedures should provide an anabolic effect on the grafted cells.
Keywords: cartilage explants; fibrin matrix; proteoglycan; metabolism; polymers; defects
L.A. Fortier, A.J. Nixon, G. Lust, Phenotypic expression of equine articular chondrocytes grown in three-dimensional cultures supplemented with supraphysiologic concentrations of insulin-like growth factor-I, American Journal of Veterinary Research, 2002, Vol 63, Iss 2, pp 301-305
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