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The effects of vasoactive amines found in the equine hindgut on digital blood flow in the normal horse.
Brief content of the article
The author’s reason for performing this study was that disturbances of digital blood flow are thought to be fundamental to the pathophysiology of acute laminitis. However, it is unclear which factors and events in de hindgut are responsible for a disturbance of digital blood flow. Results of earlier work of these author’s suggested that certain bacteria are capable of producing vasoactive amines which may play a role in the pathogenesis of acute laminitis (check this sectionfor more references about this topic). Amines may have digital vasoconstrictive effects (it is thought that feeding excessive starch/fructans may induce a high amine production in the hindgut). In the current study it is hypothised that amine compounds, formed by bacteria in the hindgut of horses have digital vasoconstrictor effects in vivo. To test the hypothesis the authors infused 2 amino compounds into horses and measured digital blood flow and an endogenous vasoconstrictor. The authors observed that the two amines used in this study caused a reduction of the digital blood flow. The results of this study indicated that if amine compounds are produced in the hindgut and are released into the circulation, this may contribute to selective digital vasoconstriction. The authors wrote that further study is needed in horses/ponies with naturally occurring laminitis.
Keywords: laminitus; hindgut; amine; tryptamine; phenylethylamine.
Bailey, S.R., Menzies-Gow, N.J. Marr, C.M and Elliott, J. 2004. The effects of vasoactive amines found in the equine hindgut on digital blood flow in the normal horse. Equine Veterinary Journal.36: 267-272
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