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Effects of glucosamine hydrochloride and chondroitin sulphate, alone and in combination, on normal and interleukin –1 conditioned equine articular cartilage explant mechanism
Brief content of the article
The objective of this study was to asses varying dosages of GU and CS on normal and interleukin-1α (IL-1) conditioned cartilage explants and rationalize the use of oral nutraceutical joint supplements containing glucosamine (GU) and chondroitin sulphate (CS). The authors observed no detrimental effects of GU, CS or GU+CS on cartilage metabolism. These results suggest that GU+CS may prevent cartilage degradation. The authors suggested that the combination of GU and CS might be more effective in preventing or treating osteoarthritis in horses than either product alone.
Keywords: cartilage; GAG synthesis; glycosaminoglycans.
Dechant, J.E., Baxter, G.M., Frisbie, D.D., Trotter, G.W. and McIlWraith, 2005. Effects of glucosamine hydrochloride and chondroitin sulphate, alone and in combination, on normal and interleukin –1 conditioned equine articular cartilage explant mechanism, Equine Vet. J. 37: 227-231.
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